Nitrazepam has become affiliated with extreme hepatic Issues, similar to other nitrobenzodiazepines. Nitrobenzodiazepines such as nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more poisonous into the liver than other benzodiazepines as They are really metabolically activated by CYP3A4 which may result in cytotoxicity.Tolerance t